Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts
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Date
2012Author
Mureithi, Dominic
Darwish, Wageh Sobhy
Ikenaka, Yoshinori
Kanja, Laetitia W
Type
ArticleLanguage
enMetadata
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The cytochrome P450 (CYP) 3A family is involved in the elimination processes of almost
50% of commonly used drugs. CYP3A mRNA expressions in goat and rat gastrointestinal
tracts in comparison to the liver were investigated using real-time PCR. In goats, the
expression of CYP3A-like mRNAs was comparatively higher in the liver than in the
gastrointestinal tract. The intestinal expression of CYP3A-like mRNA showed a gradual
decrease from the duodenum to the ileum. In rats, the highest CYP3A62 mRNA expression was found in the duodenum followed by the liver. This study provides insights into the contribution of CYP3A enzymes to xenobiotic metabolism, especially in small ruminants such as goats.
Citation
Japanese Journal of Veterinary Research 60(4): 205-210, 2012Publisher
Department of Public Health, Pharmacology and Toxicology