dc.contributor.author | Kiama, S G | |
dc.contributor.author | Cochand, L | |
dc.contributor.author | Karlsson, L | |
dc.contributor.author | Nicod, L P | |
dc.contributor.author | Gehr, P | |
dc.date.accessioned | 2013-03-18T06:42:08Z | |
dc.date.issued | 2001 | |
dc.identifier.citation | Journal of aerosol medicine Volume 14, number 3, 2001 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/14306 | |
dc.description.abstract | Dendritic cells play a central role in initiation of primary T lymphocyte responses to foreign
antigens. Their potency in antigen presentation vis-à-vis reported low or lack of ability to
phagocytize particulate matter has limited our understanding of the role that they play in inducing
immunity to particulate antigens. One hypothesis is that dendritic cells may possess
a high phagocytic capacity when immature and located in peripheral tissues, which they lose
on maturation. Our goal was to characterize the phagocytic capacity in human immature dendritic
cells. The phagocytic capacity of human monocyte-derived immature dendritic cells was
studied by morphological and morphometric means, and compared to that of professional
phagocytes, human alveolar macrophages, their progenitors, the peripheral blood monocytes,
and mature dendritic cells. Phagocytic index (proportion of phagocytic cells) was decreased
by 42.8% (immature dendritic cells) and 74.2% (mature dendritic cells) with respect to monocytes.
Similarly, the phagocytic index was decreased by 46.5% (immature dendritic cells) and
75.9% (mature dendritic cells) with respect to macrophages. Volume density of phagocytized
particles was decreased by 76.1% (immature dendritic cells) and 96.7% (mature dendritic cells)
with respect to the monocytes. However, volume density was decreased by 34.3% (immature
dendritic cells) and 91% (mature dendritic cells) with respect to alveolar macrophages. These
results show that human monocyte-derived immature dendritic cells possess a phagocytic capacity
that is lower than that of peripheral blood monocytes and alveolar macrophages but
higher than that of mature dendritic cells. | en |
dc.language.iso | en | en |
dc.title | Evaluation of phagocytic activity in human monocyte-derived dendritic cells | en |
dc.type | Article | en |
local.publisher | Institute of Anatomy, University of Berne, Berne, Switzerland. | en |
local.publisher | Division of Pneumology, University Hospital of Geneva, Geneva, Switzerland. | en |