dc.contributor.author | Dreher, Donatus | |
dc.contributor.author | Kok, Menno | |
dc.contributor.author | Obregon, Carolina | |
dc.contributor.author | Kiama, S G | |
dc.contributor.author | Gehr, Peter | |
dc.contributor.author | Nicod, Laurent P. | |
dc.date.accessioned | 2013-03-18T07:07:38Z | |
dc.date.issued | 2002 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/14331 | |
dc.description.abstract | Interleukin-18 (IL-18) plays an important
role in innate and acquired immunity, in particular
against intracellular pathogens. However,
little is known about the microbial factors that
trigger IL-18 secretion by dendritic cells (DCs). To
determine the influence of bacterial virulence factors
on the activation and release of IL-18, we
infected human monocyte-derived DCs with virulence
mutants of the facultative intracellular pathogen
Salmonella typhimurium. Our results show that
infection by S. typhimurium causes caspase-1-dependent
activation of IL-18 and triggers the release
of IL-18 in human DCs. The secretion of
IL-18 by the DCs was closely correlated with the
ability of the S. typhimurium strains to induce apoptosis.
We demonstrate that activation and release
of IL-18 are blocked by mutations in the
Salmonella sipB gene, which encodes a virulence
factor that activates caspase-1 to induce apoptosis.
These findings indicate that the activation and release
of IL-18 induced by bacterial virulence factors
may represent one component of innate immunity
against the intracellular bacteria. J. Leukoc.
Biol. 72: 743–751; 2002. | en |
dc.language.iso | en | en |
dc.subject | antigen-presenting cells | en |
dc.subject | cytokines | en |
dc.subject | innate immunity | en |
dc.subject | bacteria | en |
dc.subject | host defense | en |
dc.title | Salmonella virulence factor SipB induces activation and release of IL-18 in human dendritic cells | en |
dc.type | Article | en |
local.publisher | Division of Pneumology, University Hospital of Geneva, Switzerland | en |
local.publisher | Department of Genetics and Microbiology | en |
local.publisher | Department of Medical Biochemistry, University of Geneva, Switzerland | en |
local.publisher | Institute of Anatomy, University of Berne, Switzerland | en |
local.publisher | Department of Veterinary Anatomy, University of Nairobi, Kenya | en |