| dc.description.abstract | Mosquito larval control is an important component in malaria vector control package which has
been neglected for quite long time, but recently, a renewed interest on this tool has been observed
by introduction of IGRs in field tests. In this study, the efficacy of the IGR pyriproxyfen,
(registered as Sumilarv®) against Anopheles gambiae s.s larvae was determined. Susceptibility of
the malaria vector to the different concentrations of Sumilarv.w0.5G was tested under controlled
conditions in screened green house. Effects of IGR in controlling the malaria vector were
determined in the field where 18 plastic tubs of 20 liters capacity were buried on the ground with a
spade of soil and 17 liters of water. Fifty, fourth and third instar of An. gambiae s.s (Mbita strain)
were introduced for effectiveness of the IGR and treatment intervals under field condition.
Emergence inhibition monitoring tool was also tested. Anopheles gambiae s.s was highly
susceptible to pyriproxyfen 0.5G The 50% and 90% emergence inhibitions (El) "v'ere as 10\\1" as
8.8*10-7 (3.0*10-7 - 1.8*10-6) and 1.8*10-4 (7.4*10-5 - 7.6*10-4), respectively. Dose responses were
significantly different (P<O.O1- 95% CI). In the field experiment, effectiveness was 100% at
O.Olppm active ingredient (ai) the lowest dose recommended by the manufacturer. but its potency
dropped down to 23.3% after 7 days. The highest recommended dose (0.05ppm a i.) was equally
effective but its efficacy decreased down to 33.4% after one week. At higher dosages beyond the
recommended range, the residual effect varied, ranging from 7, 14, 28 and 60 days. The mosquito
emergence inhibition monitoring tool was useful in determining the potency although there are
more challenges when using it in an operational environment. Price was compared between Bti and
pyriproxyfen where Bti was found to be relatively cost effective compared to pyriproxyfen
O.Olppm a.i. Climatic and physical environmental conditions in tropical Africa could be the
influence on the lack of residual effect observed. | en |
