Gross and histopathological findings in Cercopithecus aethiops with experimental Cyclospora infection in Kenya
Date
2012Author
Nguhiu, P N
Wamae, C N
Magambo, J K
Mbuthia, P G
Chai, D C
Yole, D S
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
In 2009, experimental Cyclospora infections were established in two juvenile female and two adult male Cercopithecus aethiops (African green monkeys) at Nairobi's Institute of Primate Research (IPR). The study animals were humanely sacrificed, and gross and histopathological evaluation was done at seven weeks post-infection. On gross examination, the juveniles had no abnormalities except for a slight enlargement of the mesenteric lymph nodes, while the adults displayed more pathology of enlarged lymph nodes, hemorrhagic gastrointestinal tracts, widespread necrotic foci of the liver, and enlarged spleens. Significant histopathological findings were observed in both the juveniles and adults, which ranged from mild inflammatory reactions in the stomach and intestines to intense cellular infiltrations with mitotic activity and lymphocytic infiltrations around the periportal area of the livers. The lymph nodes had extensive hyperplasia with many mitotic cells.
URI
http://dx.doi.org/10.2147/PLMI.S28142http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/14375
Publisher
Pathology and Laboratory Medicine International Department of Veterinary Pathology, Microbiology and Parasitology
Subject
Cyclospora spp.cyclosporiasis
nonhuman primates
pathological findings
histopathological findings
African green monkeys