Show simple item record

dc.contributor.authorOwor, R. O.,
dc.contributor.authorBedane, K. G.
dc.contributor.authorZühlke, S.
dc.contributor.authorDerese, S.
dc.contributor.authorOng’amo, G. O.
dc.contributor.authorNdakala, A.
dc.contributor.authorSpiteller, M
dc.identifier.citationOwor, R. O., Bedane, K. G., Zühlke, S., Derese, S., Ong’amo, G. O., Ndakala, A., & Spiteller, M. (2020). Anti-inflammatory Flavanones and Flavones from Tephrosia linearis. Journal of Natural Products, 83(4), 996-1004.en_US
dc.description.abstractPhytochemical analysis of a methanol–dichloromethane (1:1) extract of the aerial parts of Tephrosialinearis led to the isolation of 18 compounds. Seven of these, namely, lineaflavones A–D (1–4), 6-methoxygeraldone (5), 8″-acetylobovatin (6), and 5-hydroxy-7-methoxysaniculamin A (7) are new compounds. The compounds were characterized based on their NMR and HRMSn data. The anti-inflammatory effects of the crude extract and isolated compounds were evaluated by measuring the levels of interleukins (IL-1β, IL-2, and IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). The crude extract inhibited the release of all cytokines except IL-1β, which slightly increased in comparison to the LPS control. All the tested compounds suppressed the production of IL-2, GM-CSF, and TNF-α. Whereas compounds 1, 2, 4–8, 10–15, 17, and 18 decreased production of IL-6, compounds 1, 2, 4, 7, 10, 13–15, and 17 inhibited the release of IL-1β. It is worth noting that most of the compounds tested showed a superior reduction in cytokines release compared to the reference drug ibuprofen.en_US
dc.titleAnti-inflammatory Flavanones and Flavones from Tephrosia linearisen_US

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record