dc.contributor.author | Kioko, Magdaline W | |
dc.contributor.author | Mute, L | |
dc.contributor.author | Akivaga, K | |
dc.date.accessioned | 2020-11-18T06:35:35Z | |
dc.date.available | 2020-11-18T06:35:35Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | WANZA MSKIOKOMAGDALENE. "Kioko, W.M., Mute, L., and Akivaga, K., (Eds.) Building an Open Society: The Politics of Transition in Kenya (Nairobi: Clairpress, 2002) (Editor).". In: American Journal of Obstetric and Gynaecology Vol 101 . Starmat Designers & Allied, Nairobi; 2002. | en_US |
dc.identifier.uri | https://profiles.uonbi.ac.ke/wanza/publications/kioko-wm-mute-l-and-akivaga-k-eds-building-open-society-politics-transition-kenya | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/153379 | |
dc.description.abstract | Cohen CR, Gichui J, Rukaria R, Sinei SS, Gaur LK, Brunham RC. Departments of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USA. crcohen@u.washington.edu OBJECTIVE: To understand immunogenetic mechanisms of Chlamydia trachomatis infection and tubal scarring. METHODS: We measured and compared previously significant human leukocyte antigen (HLA) class II DQ alleles, their linked DRB genes, and polymorphisms in selected cytokine genes (tumor necrosis factor alpha-308 promoter; transforming growth factor beta1-10 and -25 codons; interleukin 10-1082, -819, and -592 promoters; interleukin 6-174 promoter; and interferon gamma+874 codon 1) among Kenyan women with confirmed tubal infertility with and without C trachomatis microimmunofluorescence antibody. RESULTS: Two class II alleles, HLA-DR1*1503 and DRB5*0101, were detected less commonly in C trachomatis microimmunofluorescence seropositive women than in C trachomatis microimmunofluorescence seronegative women with infertility (0% versus 20%; odds ratio [OR] 0.05; 95% confidence interval [CI] 0, 0.7, and 6% versus 26%; OR 0.2; 95% CI 0.02, 1.0, respectively). These alleles are commonly linked as a haplotype at the DRB locus. This finding could not be explained through linkage disequilibrium with the other studied HLA or cytokine genes. CONCLUSION: These alleles may lead to an immunologically mediated mechanism of protection against C trachomatis infection and associated tubal damage, or alternatively increase risk for tubal scarring due to another cause. PMID: 12636945 [PubMed - indexed for MEDLINE] | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.title | Building an Open Society: the Politics of Transition in Kenya (Nairobi: Clairpress, 2002) | en_US |
dc.type | Article | en_US |