dc.contributor.author | Cyr, Jennifer L. | |
dc.contributor.author | Gawriluk, Thomas R. | |
dc.contributor.author | Kimani, John M. | |
dc.contributor.author | Rad, Balazs | |
dc.contributor.author | Watford, Wendy T. | |
dc.contributor.author | Kiama, Stephen G. | |
dc.contributor.author | Seifert, shley W. | |
dc.contributor.author | Ezenwa, anessa O. | |
dc.date.accessioned | 2021-09-29T07:22:59Z | |
dc.date.available | 2021-09-29T07:22:59Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Cyr JL, Gawriluk TR, Kimani JM, Rada B, Watford WT, Kiama SG, Seifert AW, Ezenwa VO. "Regeneration-competent and-incompetent murids differ in neutrophil quantity and function.". 2019. | en_US |
dc.identifier.uri | https://watermark.silverchair.com/icz023.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAtYwggLSBgkqhkiG9w0BBwagggLDMIICvwIBADCCArgGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMW1LBc0OHOuP5JBDJAgEQgIICia7gV05hm-e8unOs4CdrC9X5cZjIsSXevVMRw2Akpp0LCb5ReZ-ifLAVvqss7TkYYcRNpVrSCEF6BQ1eDW-Kh3WWFRT1FzJHC5G8bY1YKjqkz4AJV_JDMmuNQ9gqjZ617bno7uVD2xsLPs_9EKSXvbR9Rz67OSkMemtWnogcrhqkttvjHuH4LuJjc_rF-PegQBOPD92EgCFqnplb4mO6PG2Eq6fOnRiGRMpY93VfkQkZJFAkYjy1ZmjnUlGuJPPxFHcwuk21Cx2oas87VmrUVPxyIRzRz5ArZ5TBJZm9WZPXHFOfG6IFICH99ekrL8BdNbyu_CkT88byDSDa46I_sIiodisf4oRnUuY9AmecH1Vf4a8ydWyvcD_rBxQEaXn5lqonfs8ly3iy7Hkvf-ndNjEV_vkkwFQrWfjREvL_63fCfjW4_haw6mIByxYK0SNlFM07GeN7IbXiBx_4Dyd9i7BsuoDu97-ax0A5f9i-yJtWotEhZeq64ZyP2BDR2tFZppShTJzTFCIoS6ZsAvfUCTTmFdzdCb9cwvAxZL4buAdBGmQ10iVjsXDnrehi_jWb927-9H1BctagUtRnfkuP1Udz_0_hbtwqXFHng6egXjlrm8fEpZj77FZM7kuF-Sr4Lrxtuewb9Recsc113nBVQmxmQtOL6Nbl_CF3LHMJubK7o_oRDK-orfpehzfq4fWaVTqjRC9zUQe28vlsUVZmVzqp3l3fP4YSvoEMUspcAIOqhzhfbomyaL4YOIpyaNIKjSHYppN70dAdjeN0xruB64Pp2ItzTUG2aGgWKd9HPLJJ41WzG4COhZ0RqL8ZdR77dRdw8l1L9mZsZxzYAeqD0UZD2ECQQpw-g7I | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/155546 | |
dc.description.abstract | Synopsis Regeneration is rare in mammals, but spiny mice (Acomys spp.) naturally regenerate skin and ear holes.
Inflammation is thought to inhibit regeneration during wound healing, but aspects of inflammation contribute to both
regeneration and pathogen defense. We compared neutrophil traits among uninjured, regeneration-competent (Acomys:
A. cahirinus, A. kempi, A. percivali) and -incompetent (Mus musculus: Swiss Webster, wild-caught strains) murids to test
for constitutive differences in neutrophil quantity and function between these groups. Neutrophil quantity differed
significantly among species. In blood, Acomys had lower percentages of circulating neutrophils than Mus; and in
bone marrow, Acomys had higher percentages of band neutrophils and lower percentages of segmented neutrophils.
Functionally, Acomys and Mus neutrophils did not differ in their ability to migrate or produce reactive oxygen species,
but Acomys neutrophils phagocytosed more fungal zymosan. Despite this enhanced phagocytosis activity, Acomys neu-
trophils were not more effective than Mus neutrophils at killing Escherichia coli. Interestingly, whole blood bacteria
killing was dominated by serum in Acomys versus neutrophils only or neutrophils and serum in Mus, suggesting that
Acomys primarily rely on serum to kill bacteria whereas Mus do not. These subtle differences in neutrophil traits may
allow regeneration-competent species to offset damaging effects of inflammation without compromising pathogen
defense. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.title | Regeneration-competent and-incompetent Murids Differ in Neutrophil Quantity and Function | en_US |
dc.type | Article | en_US |