dc.contributor.author | Jepkoech, Clara | |
dc.contributor.author | Omosa, Leonidah K | |
dc.contributor.author | Nchiozem-Ngnitedem, Vaderament-A | |
dc.contributor.author | Kenanda, Evans O | |
dc.contributor.author | Guefack, Michel-Gael F | |
dc.contributor.author | Mbaveng, Armelle T | |
dc.contributor.author | Kuete, Victor | |
dc.contributor.author | Heydenreich, Matthias | |
dc.date.accessioned | 2022-10-04T06:41:42Z | |
dc.date.available | 2022-10-04T06:41:42Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/14786419.2021.1953024 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/161400 | |
dc.description.abstract | Purification of the aerial parts of Vernonia auriculifera Hiern
afforded steroids (1–2), flavonoids (3–5), and polyalcohol (6).
Their structures were determined using spectral evidences as well
as by comparison with reported data. Iodonitrotetrazolium chlor-
ide (INT) colorimetric assay was used to assess the antibacterial
activity of the extract and isolates against 13 pathogenic strains.
The crude extract showed strong antibacterial activity (MIC <
100 mg/mL) against the tested bacterial strains. When combined
with an efflux pump inhibitor phenylalanine beta naphthylamide
(PAbN), the inhibition potency of the extract was substantially
enhanced with the lowest MIC value at 4 mg/mL. Compounds 5
and 6 showed moderate activity (MIC < 100 mg/mL) against 12/13
(92.3%), and 8/13 (61.5%) bacterial strains, respectively. A minimal
bactericidal concentration (MBC)/minimal inhibitory concentration
(MIC) ratio 4 indicated their bactericidal effect against
Escherichia coli, Enterbacter aerogenes, Klebsiella pneumoniae,
Providencia stuartii, Pseudomonas aeruginosa, and
Staphylococcus aureus. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.title | Antibacterial Secondary Metabolites From Vernonia Auriculifera Hiern (Asteraceae) Against Mdr Phenotypes | en_US |
dc.type | Article | en_US |