Risk factors and outcomes among TB/HIV coinfected children
Abstract
TUberculosis (TB) being the most common opportunistic infection in human immunodeficiency
virus (HIV)-infected people worldwide has attracted a lot of interest in
research. TB manifestations are more severe in HIV-positive children and progression
to death is more rapid than in HIV-negative children. TB also hastens the progression
of HIV disease by increasing viral replication and reducing CD4 counts further.
We performed a retrospective cohort study at a large HIV initiation site-Kenyatta
National Hospital CCC, and use Generalized Estimating Equations to longitudinally
identify predictors of incidence and risk factors among children initiated HAART, and
in particular to determine the impact of TB co treatment on the outcomes among
children with confirmed TB/HIV. Results showed that, for fifty one children who had
information onCD4 before TB treatment and after completing TB treatment. The
median CD4 percent beforexwas 10% (IQR: 7: 15.6) and 29 (IQR: 20.5: 42.7) after
completing TB treatment. Before starting TB treatment, 62.8% of children were
immune-suppressed and this proportion reduced to 19.6% after treatment. The difference
in the proportion.of immune-suppressed children was statistically significant using
McNemar test (p-value =0.001)
Citation
M.Sc (Biometry)Sponsorhip
University of NairobiPublisher
School of Mathematics, University of Nairobi
Description
Master of Science Thesis