| dc.description.abstract | In vitro products and saline soluble antigens derived from
Taenia taeniaeformis metacestodes were shown to stimulate significant
resistance against challenge in rats. Unless necessary, for
experimental purposes, each rat was vaccinated with Img of antigen
as determined by its protein content. Both antigens were effective
when administered alone orally and intraperitoneally, but required
adjuvants when given intramuscularly. Bordetella pertussis
considerably enhanced the protective effects of the antigens
when given with the intraperitoneal and intramuscular vaccinations.
Aluminum hydroxide was also shown to be an adequate adjuvant.
Freund's complete adjuvant was found to be ineffective in improving
the resistance stimulated by either antigen.
With the oral route, it was found that administration of the
dose of in vitro products equally divided over five days provided
significantly more resistance than giving the dose once only.
Increasing the dosage of the saline soluble antigens given orally
and giving the antigen at intervals over a two week period,
. did not improve the resistance. B. pertussis failed to improve
the resistance stimulated by orally administered saline soluble
antigens, whether the adjuvant was given together with the antigen
or separately in the musculature. Both antigens were shown to
confer a systemic resistance when given per os.
Low levels of homocytotropic antibody were detected in rats
immunized intramuscularly with either antigen using B. pertussis
or aluminum hydroxide as adjuvants. None was detectable in those
rats immunized orally or intramuscularly using Freund's complete
adjuvant with either antigen.
Passive transfer of resistance was not observed in recipients
of serum from rats that had been vaccinated orally or intramuscularly
with either antigen employing B. pertussis as an adjuvant. | en |
