Humoral Immune Responses in Olive Baboons (Papio Anubis) Vaccinated With Either Radio-attenuated Schistosoma Mansoni Cercariae or Anti-idiotypic Antibodies
dc.contributor.author | Borus, Peter K | |
dc.date.accessioned | 2013-05-26T09:32:45Z | |
dc.date.available | 2013-05-26T09:32:45Z | |
dc.date.issued | 1994 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/25908 | |
dc.description.abstract | Rabbits innoculated with purified baboon anti-cercariae antibodies (Ab 1) produced second generation antibodies 2 weeks post-vaccination as detected by radial immunodiffusion test. Anti-idiotypic antibodies (Ab2) purified from the second generation antibodies produced a 32% inhibition against Ab 1 binding to transformed schistosornula antigen compared to 87% inhibition produced by the schistosomula antigen when used in place of Ab2. Vaccination of5 baboons (Papio anubis) with the anti-idiorypic antibodies to irradiated Schistosoma mansoni cercariae resulted in intermediate antibody levels as compared to the high antibody levels obtained in sera of baboons exposed to irradiated cercariae. There was a 19% reduction in worm burden on perfusion of the 5 baboons compared to a 39% reduction in 5 baboons vaccinated with the irradiated vaccine. Vaccination with the anti-idiotypic antibodies resulted in significant reduction of pathology size following challenge with live unattenuated cercariae. Results presented in this work are considered highly significant because the anti-idiotypic vaccine markedly influenced schistosomiasis morbidity which is the main consideration in this disease. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi, | en |
dc.title | Humoral Immune Responses in Olive Baboons (Papio Anubis) Vaccinated With Either Radio-attenuated Schistosoma Mansoni Cercariae or Anti-idiotypic Antibodies | en |
dc.type | Thesis | en |
local.publisher | Department of Mathematics | en |
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