Ring Opening of 1,5-Dioxaspiro[3.2]hexanes: Selective Preparation of alpha-Heterofunctionalized- beta'-hydroxy Ketones or 2,2-Disubstituted Oxetanes
Date
1999Author
J, Ndakala Albert
R, Howell Amy
Type
ArticleLanguage
enMetadata
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Abstract.................................. Image
2-Methyleneoxetanes have been converted into 1,5-dioxaspiro[3.2]hexanes with dimethyldioxirane. Reaction of the dioxaspirohexanes with a range of heteroatom nucleophiles, hydride donors, or organoaluminum reagents was successful under neutral or mild conditions, affording, selectively, polyfunctionalized ketones or 2,2-disubstituted oxetanes.
URI
http://pubs.acs.org/doi/abs/10.1021/ol990039chttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/27933
Citation
Ring Opening of 1,5-Dioxaspiro[3.2]hexanes: Selective Preparation of alpha-Heterofunctionalized- beta'-hydroxy Ketones or 2,2-Disubstituted Oxetanes, Howell, Amy R., and Ndakala Albert J. , Organic Letters, Volume 1, p.825-827, (1999) copy at http://profiles.uonbi.ac.ke/andakala/publications/ring-opening-15-dioxaspiro32hexanes-selective-preparation-heterofunctionalizedPublisher
Department of Chemistry