dc.contributor.author | Roxby, AC | |
dc.contributor.author | Liu, AY | |
dc.contributor.author | Drake, AL | |
dc.contributor.author | Kiarie, JN | |
dc.contributor.author | Richardson, B | |
dc.contributor.author | Lohman-Payne, BL | |
dc.contributor.author | John-Stewart, GC | |
dc.contributor.author | Wald, A | |
dc.contributor.author | De Rosa, S | |
dc.contributor.author | Farquhar, C | |
dc.date.accessioned | 2013-06-12T12:00:35Z | |
dc.date.available | 2013-06-12T12:00:35Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Short communication: T cell activation in HIV-1/herpes simplex virus-2-coinfected Kenyan women receiving valacyclovir. Roxby AC, Liu AY, Drake AL, Kiarie JN, Richardson B, Lohman-Payne BL, John-Stewart GC, Wald A, De Rosa S, Farquhar C. AIDS Res Hum Retroviruses. 2013 Jan;29(1):94-8. doi: 10.1089/AID.2012.0071. Epub 2012 Sep 4. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/22852760 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32260 | |
dc.description.abstract | Herpes simplex virus-2 (HSV-2) suppression with acyclovir or valacyclovir reduces HIV-1 viral RNA levels; one hypothesis is that HSV-2 suppression reduces immune activation. We measured T cell immune activation markers among women participating in a randomized placebo-controlled trial of valacyclovir to reduce HIV-1 RNA levels among pregnant women. Although valacyclovir was associated with lower HIV-1 RNA levels, the distribution of both CD4(+) and CD8(+) CD38(+)HLA-DR(+) T cells was not different among women taking valacyclovir when compared to women taking placebo. Further study is needed to understand the mechanism of HIV-1 RNA reduction following herpes suppression among those coinfected with HIV-1 and HSV-2. | en |
dc.language.iso | en | en |
dc.title | Short communication: T cell activation in HIV-1/herpes simplex virus-2-coinfected Kenyan women receiving valacyclovir. | en |
dc.type | Article | en |
local.publisher | Medicine, University of Washington, Seattle | en |