| dc.contributor.author | Mwangi, DM | |
| dc.contributor.author | McKeever, DJ | |
| dc.contributor.author | Mahan, SM | |
| dc.date.accessioned | 2013-06-13T13:58:58Z | |
| dc.date.available | 2013-06-13T13:58:58Z | |
| dc.date.issued | 1998 | |
| dc.identifier.citation | Dev Biol Stand. 1998;92:309-15. | en |
| dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/9554286 | |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/33264 | |
| dc.description.abstract | Peripheral blood mononuclear cells (PBM) from cattle immunised against Cowdria ruminantium infection (Heartwater), proliferated in vitro in the presence of either infected autologous endothelial cells pre-treated with T cell growth factors to induce MHC class II expression, or infected autologous monocytes. Proliferation was not observed in PBM cultured with a soluble extract of the agent, but PBM responded to two recombinant antigens of C. ruminantium, namely a 32 kDa (MAP1) and a 21 kDa antigen (MAP2). We hypothesize that infected endothelial cells and monocytes present Cowdria antigens to specific lymphocytes during infection and thereby play a role in the pathogenesis/immune response to the pathogen | en |
| dc.language.iso | en | en |
| dc.publisher | University of Nairobi. | en |
| dc.title | Cellular immune responses of cattle to Cowdria ruminantium. | en |
| dc.type | Article | en |
| local.publisher | Department of Veterinary Pathology and Microbiology, University of Nairobi, Kenya. | en |
