Solid-phase peptide synthesis of isotocin with amide of asparagine protected with 1-tetralinyl. Rifluoromethanesulphonic acid (tfmsa) deprotection, cleavage and air oxidation of mercapto groups to disulphide

dc.contributor.author	Amir, O. Yusuf
dc.contributor.author	Bhatt, Bhalendu M
dc.contributor.author	Gitu, Peter M
dc.date.accessioned	2013-06-13T14:25:03Z
dc.date.issued	2001
dc.identifier.citation	Bu ll. Chem. Soc. Eth iop. 2001, 15(2), 143-149.	en
dc.identifier.issn	1011-3924
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/33280
dc.description.abstract	Isotocin, a nonapept ide amide, was synthesised on a benzhydryl-resin using the Bocst rat egy. Benzyl group was used in the pr otect ion of the side-ch ains of tyrosine, ser ine and cyst eine. Tetr alinyl group was used to protect aspar agine side-chain. TFMSA-TFA-thioanisole-1,2- ethanedithiol (2:20:2:1 v/v) was used on the pept ide-r esin under different cleavage conditions to obtain isotocin in a one-pot rea ct ion. The cleavage at 40 °C for two hours gave isotocin quantitatively. Isotocin could be isolated in 61% yield.	en
dc.language.iso	en	en
dc.subject	Isot ocin	en
dc.subject	Nonapept ide amide	en
dc.subject	Tyrosine	en
dc.subject	Serine	en
dc.subject	Cysteine	en
dc.subject	Aspar agine	en
dc.subject	Tet ralinyl group	en
dc.title	Solid-phase peptide synthesis of isotocin with amide of asparagine protected with 1-tetralinyl. Rifluoromethanesulphonic acid (tfmsa) deprotection, cleavage and air oxidation of mercapto groups to disulphide	en
dc.type	Article	en
local.publisher	Department of Chemistry, University of Nairobi	en