dc.contributor.author | Langat, Daudi K. | |
dc.contributor.author | Johnson, Peter M. | |
dc.contributor.author | Rote, Neal S. | |
dc.contributor.author | Wango, Emmanuel O. | |
dc.contributor.author | Owiti, George O. | |
dc.contributor.author | Mwenda, Jason M. | |
dc.date.accessioned | 2013-06-14T07:46:01Z | |
dc.date.available | 2013-06-14T07:46:01Z | |
dc.date.issued | 2011-09 | |
dc.identifier.citation | Journal of Medical Primatology Volume 27, Issue 6, pages 278–286, December 1998 | en |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0684.1998.tb00076.x/abstract | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/33594 | |
dc.description.abstract | Abstract: Endogenous retroviral particles (ERVs) have been detected in the genome of all eukaryotes. They are generally non-pathogenic except in mice where they have been found to induce tumors and immunological disorders. The ERVs have morphological features consistent with type-C retroviral particles and are commonly expressed in normal placental villous tissues. ERVs may have a role in the regulation of placental gene expression, syncytiotrophoblast formation, or pregnancy-related immunosuppression. In this study, well-characterized antibodies (monoclonal and polyclonal antibodies) raised against retroviral proteins (anti-HIV and anti-SIV) and endogenous retroviral (ERV) particles were assessed for their cross-reactivity (by using immunohistochemistry) with normal baboon placental and other adult tissues. The monoclonal antibodies to exogenous retroviral proteins (anti-HIV-2 gp120, anti-HIV-1 gp41, anti-SIVmac p27, anti-HIV-1 RT, and anti-HIV-2 core protein) showed specific immunohistochemical reactivity with the syncytiotrophoblast. Antibodies to endogenous retroviral gene products (anti-ERV3 env, anti-HERV-K RT, and anti-HERV-K env) also reacted in a similar manner and did not cross-react with other adult tissues. These studies have shown that retroviral-cross-reactive proteins are expressed in baboon placental syncytiotrophoblast and may have a role to play at the feto-maternal interface. | en |
dc.language.iso | en | en |
dc.publisher | Univesity of Nairobi | en |
dc.title | Immunohistochemical localization of retroviral‐related antigens expressed in normal baboon placental villous tissue | en |
dc.type | Article | en |
local.publisher | Department of Vetinary Anatomy and physiology | en |