Relationships between host blood factors and proteases in Glossina morsitans subspecies infected with Trypanosoma congolense
Date
1995Author
Otieno, Leonard H
Kang'ethe, Rastus K
Darji, Nafisa
Machika, Christopher
Mihok, Steve
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Host blood effects on Trypanosoma congolense establishment in Glossina morsitans morsitans and Glossina morsitans centralis were investigated using goat, rabbit, cow and rhinoceros blood. Meals containing goat erythrocytes facilitated infection in G. m. morsitans, whereas meals containing goat plasma facilitated infection in G. m. centralis. Goat blood effects were not observed in the presence of complementary rabbit blood components. N-acetyl-glucosamine (a midguMectin inhibitor) increased infection rates in some, but not all, blood manipulations. Cholesterol increased infection rates in G. m. centralis only. Both compounds together added to cow blood produced superinfection in G. m. centralis, but not in G. m. morsitans. Midgut protease levels did not differ 6 days post-infection in flies maintaining infections versus flies clearing infections. Protease levels were weakly correlated with patterns of infection, but only in G. m. morsitans. These results suggest that physiological mechanisms responsible for variation in infection rates are only superficially similar in these closely-related tsetse.
Citation
Volume 9, Issue 2, pages 155–160, April 1995Publisher
Department of Public Health, Pharmacology and Toxicology