Two unusual rotenoid derivatives, 7a-O-methyl-12a-hydroxydeguelol and spiro-13-homo-13-oxaelliptone, from the seeds of Derris trifoliata
Date
2006-05Author
Yenesew Abiy.
Kiplagat JT.
Derese Solomon.
Midiwo Jacob O.
Kabaru JM.
Heydenreich M.
Peter MG.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The crude methanol extract of the seeds of Derris trifoliata showed potent and dose dependent larvicidal activity against the 2nd instar larvae of Aedes aegypti. From this extract two unusual rotenoid derivatives, a rotenoloid (named 7a-O-methyl-12a-hydroxydeguelol) and a spirohomooxarotenoid (named spiro-13-homo-13-oxaelliptone), were isolated and characterised. In addition a rare natural chromanone (6,7-dimethoxy-4-chromanone) and the known rotenoids rotenone, tephrosin and dehydrodeguelin were identified. The structures were assigned on the basis of spectroscopic evidence. The larvicidal activity of the crude extract is mainly due to rotenone.
URI
http://www.sciencedirect.com/science/article/pii/S0031942206000045http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34442
http://www.ncbi.nlm.nih.gov/pubmed/16483619
Citation
Phytochemistry. 2006 May;67(10):988-91. Epub 2006 Feb 17.Sponsorhip
The crude methanol extract of the seeds of Derris trifoliata showed potent and dose dependent larvicidal activity against the 2nd instar larvae of Aedes aegypti. From this extract two unusual rotenoid derivatives, a rotenoloid (named 7a-O-methyl-12a-hydroxydeguelol) and a spirohomooxarotenoid (named spiro-13-homo-13-oxaelliptone), were isolated and characterised. In addition a rare natural chromanone (6,7-dimethoxy-4-chromanone) and the known rotenoids rotenone, tephrosin and dehydrodeguelin were identified. The structures were assigned on the basis of spectroscopic evidence. The larvicidal activity of the crude extract is mainly due to rotenonePublisher
Department of Zoology, University of Nairobi, Department of Chemistry, University of Nairobi Institut für Chemie, Universität Potsdam, P.O. Box 601553, D-14415 Potsdam, Germany
Subject
Derris trifoliataLeguminosae
Seeds
Rotenoloid
Spirohomooxarotenoid
Rotenoids
7a-O-methyl-12a-hydroxydeguelol
Spiro-13-homo-13-oxaelliptone
6,7-Dimethoxy-4-chromanone
Mosquito
Larvicides
Aedes aegypti