Antimicrobial and antiparasitic abietane diterpenoids from the roots of Clerodendrum eriophyllum
Date
2010-06Author
Derese Solomon.
Machumi F.
Samoylenko V.
Yenesew Abiy.
Midiwo Jacob O.
Wiggers FT.
Jacob MR
Tekwani BL.
Khan SI.
Walker LA.
Muhammad I.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Chromatographic separation of the roots of a Kenyan medicinal plant, Clerodendrum eriophyllum, led to the isolation of ten abietane diterpenoids (1-10), one of which (1) was isolated for the first time from a natural source. Using spectroscopic data, the structure of 1 was determined to be 12-hydroxy-8,12-abietadiene-3,11,14-trione. Circular dichroism (CD) spectra showed that the stereochemistry of compounds 1, 3, and 6-8 belongs to the normal series of abietane diterpenes, which confirmed the absolute stereochemistry of the isolated compounds. Compounds 1-10 were evaluated for their in vitro antiplasmodial, antileishmanial, antifungal and antibacterial activities. Compounds 3 and 7 exhibited potent antifungal activity (IC50/MIC 0.58/1.25 and 0.96/2.5 microg/mL, respectively) against C. neoformans, whereas 3, 6 and 7 showed strong antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus with IC50/MIC values between 1.33-1.75/2.5-5 and 0.96-1.56/2.5 microg/mL, respectively. In addition, compounds 3 and 9 exhibited potent antileishmanial activity (IC50 0.08 and 0.20 microg/mL, respectively) against L. donovani, while 3 and 7 displayed weak antimalarial activity against Plasmodium falciparum, but 9 was inactive.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34894http://www.ncbi.nlm.nih.gov/pubmed/20614808
Citation
Nat Prod Commun. 2010 Jun;5(6):853-8.Publisher
University of Nairobi College of biological and physical science