Antiplasmodial Flavonoids from Erythrina sacleuxii
Date
2006-02Author
Andayi, Andrew W
Yenesew, Abiy
Derese, Solomon
Midiwo, Jacob O
Gitu, Peter M
Jondiko, Ogoche J I
Akala, Hosea
Liyala, Pamela
Wangui, Julia
Waters, Norman C
Heydenreich, Matthias
Peter, Martin G
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4′-methoxy-3′-prenylisoflavone (trivial name 5-deoxy-3′-prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sacleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence.
URI
https://www.thieme-connect.com/ejournals/abstract/10.1055/s-2005-873200http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34983
http://www.ncbi.nlm.nih.gov/pubmed/16491458
Citation
Planta Med 2006; 72(2): 187-189;DOI: 10.1055/s-2005-873200Publisher
University of Nairobi Department of Chemistry, University of Nairobi Department of Chemistry, Maseno University