Two New Antiprotozoal 5-Methylcoumarins from Vernonia brachycalyx
Date
1997Author
Oketch-Rabah, HA
Lemmich, E
Dossaji, SF
Thor, GT
Carl, EO
Claus, C
Arsalan, K
Brøgger, SC
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Two new isomeric 5-methylcoumarins, 2‘-epicycloisobrachycoumarinone epoxide (1) and cycloisobrachycoumarinone epoxide (2), have been isolated from the roots of Vernonia brachycalyx by means of bioactivity-guided fractionation. The structures were elucidated by MS and NMR spectroscopic methods. Compounds 1 and 2 showed in vitro activity against Leishmania major promastigotes and against Plasmodium falciparum schizonts and demonstrated an inhibition on the proliferation of human lymphocytes, which was significantly weaker than the antiparasitic effects.
URI
http://www.ncbi.nlm.nih.gov/pubmed/9170288http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/35016
Citation
J. Nat. Prod., 1997, 60 (5), pp 458–461Publisher
Department of Chemistry