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dc.contributor.authorAbosl AO.
dc.contributor.authorMbukwa E.
dc.contributor.authorMajinda RR.
dc.contributor.authorRaserok BH.
dc.contributor.authorYenesew Abiy.
dc.contributor.authorMidiwo Jacob O.
dc.contributor.authorAkala H.
dc.contributor.authorLiyala P.
dc.contributor.authorWaters NC.
dc.identifier.citationBr J Biomed Sci. 2006;63(3):129-33.en
dc.description.abstractVangueria infausta burch subsp. infausta (Rubiaceae) produces fruits eaten by humans and animals. The leaf, fruit, stem bark and root bark are used as a remedy for many ailments and the roots are used to treat malaria. In this study, concentrations of fractions of the V. infausta root bark extract that produce 50% inhibition (IC50) are determined using the ability of the extract to inhibit the uptake of [G3H]-hypoxanthine by P. falciparum cultured in vitro. The root bark extract showed antimalarial activity against Plasmodium berghei in mice. It gave a parasite suppression of 73.5% in early infection and a repository effect of 88.7%. One fraction obtained from a chloroform extract gave an IC50 value of 3.8 +/- 1.5 microg/mL and 4.5 +/- 2.3 microg/mL against D6 and W2 strains of P. falciparum, respectively, and another from the butanol extract gave an IC50 value of 3.9 +/- 0.3 microg/mL against the D6 strain. Chloroquine had an IC50 value of 0.016 microg/mL and 0.029 microg/mL against D6 and W2 strains, respectively. The plant showed the presence of flavonoids, coumarins, tannins, terpenoids, anthraquinones and saponins.en
dc.publisherUniversity of Nairobien
dc.titleVangueria infausta root bark: in vivo and in vitro antiplasmodial activityen
local.publisherDepartment of Biological Sciences, University of Botswanaen
local.publisherCollege of Biological and Physical Sciences,University of Nairobien

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