dc.contributor.author | De Vuyst, H | |
dc.contributor.author | Claeys, P | |
dc.contributor.author | Njiru, S | |
dc.contributor.author | Steyaert, S | |
dc.contributor.author | Muchiri, L | |
dc.contributor.author | De Sutter, P | |
dc.contributor.author | Van Marck, E | |
dc.contributor.author | Bwayo, J | |
dc.contributor.author | Temmerman, M | |
dc.date.accessioned | 2013-06-19T15:33:46Z | |
dc.date.available | 2013-06-19T15:33:46Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | International Journal of Gynecology & Obstetrics Volume 89, Issue 2, May 2005, Pages 120–126 | en |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0020729205000846 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/36428 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/15847874 | |
dc.description.abstract | Objective
To assess the test qualities of four screening methods to detect cervical intra-epithelial neoplasia in an urban African setting.
Method
Six hundred fifty-three women, attending a family planning clinic in Nairobi (Kenya), underwent four concurrent screening methods: pap smear, visual inspection with acetic acid (VIA), PCR for high risk human papillomavirus (HR HPV) and cervicography. The presence of cervical intra-epithelial neoplasia (CIN) was verified by colposcopy or biopsy.
Result
Sensitivity (for CIN2 or higher) and specificity (to exclude any CIN or cancer) were 83.3% (95% CI [73.6, 93.0]) and 94.6% (95% CI [92.6, 96.5]), respectively, for pap smear; 73.3% (95% CI [61.8, 84.9]) and 80.0% (95% CI [76.6, 83.4]) for VIA; 94.4% (95% CI [84.6, 98.8]) and 73.9% (95% CI [69.7, 78.2]) for HR HPV; and 72.3% (95% CI [59.1, 85.6]) and 93.2% (95% CI [90.8, 95.7]) for cervicography.
Conclusion
The pap smear had the highest specificity (94.6%) and HPV testing the highest sensitivity (94.4%). The visual methods, VIA and cervicography, were similar and showed an accuracy in between the former two tests.
Keywords
Cervical neoplasia screening;
Papanicolaou smear;
Human papillomavirus testing;
Cervicography;
Visual inspection with acetic acid | en |
dc.language.iso | en | en |
dc.publisher | Univesity of Nairobi | en |
dc.title | Comparison of pap smear, visual inspection with acetic acid, human papillomavirus DNA-PCR testing and cervicography | en |
dc.type | Article | en |
local.publisher | Department of Clinical studies | en |