dc.contributor.author | Varma, Vijay | |
dc.contributor.author | Abbott, Karen | |
dc.contributor.author | Gramlich, Terry | |
dc.contributor.author | Hunter, Stephen | |
dc.date.accessioned | 2013-06-20T06:29:56Z | |
dc.date.available | 2013-06-20T06:29:56Z | |
dc.date.issued | 1993-11 | |
dc.identifier.citation | Genes, Chromosomes and Cancer Volume 8, Issue 3, pages 172–177, November 1993 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/36504 | |
dc.description.abstract | Carcinoma of the esophagus shows a strong male predominance and other epidemiologic differences from cancers arising at other sites. In this study, the prevalence of Y chromosome loss in 29 carcinomas of the esophagus and 53 carcinomas arising elsewhere in the aerodigestive tract was assessed by in situ hybridization of formalin-fixed paraffin-embedded tissue sections. Absence of the Y chromosome was defined as (1) negative staining for Y in neoplastic cells with positive staining for Y in immediately adjacent nonneoplastic epithelial and stromal cells, (2) positive staining of neoplastic cells with control probes for chromosomes X and 17, and (3) similar results at different stringencies and levels of protein digestion. According to these criteria, absence of the Y chromosome was observed in 13 of 14 (93%) adenocarcinomas of the esophagus, 8 of 13 (62%) squamous cell carcinomas of the esophagus, and 5 of 53 (9%) carcinomas arising in other sites. For the neoplasms examined, Y chromosome deletion was strongly and selectively associated with carcinomas, particularly adenocarcinomas, of the esophagus (P < .0001). These findings suggest that Y chromosome loss may be pathogenetically significant in these neoplasms. | en |
dc.language.iso | en | en |
dc.title | Y chromosome loss in esophageal carcinoma: An in situ hybridization study | en |
dc.type | Article | en |
local.publisher | Department of Clinical Studies | en |