dc.contributor.author | Mwangi, PW | |
dc.contributor.author | Wambugu, SN | |
dc.contributor.author | Kariuki, DK | |
dc.contributor.author | Mbugua, PM | |
dc.contributor.author | Kanui, TI | |
dc.date.accessioned | 2013-06-20T09:25:44Z | |
dc.date.available | 2013-06-20T09:25:44Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Phytopharmacology 2011, 1(5) 148-159 | en |
dc.identifier.uri | http://www.inforesights.com/phytopharmacology/files/17.pdf | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/36682 | |
dc.description.abstract | The members of genus
Ocimum
find wide application in traditional medicine. The
current study was undertaken to evaluate
the probable mechanisms of antinocicep-
tive action of chloroform/ethanol extracts of
Ocimum masaiense
roots. The extract
was prepared by soxhlet extraction. The
mechanism of action experiments involved
administration of various blockers along with
the extract in the formalin test. Data
was analyzed using Kruksal Wallis test.
The extract possessed significant antiknoc-
iceptive activity in the formalin test
. Atropine, enhanced while Ketamine,
Capsaicin and Naloxone significantly inhibited the antinociceptive activity in the
early phase. Only capsaicin had a significant inhibitory effect on the antinocicepti-
ve activity of the extract in the late
phase among the substances tested. Based on
the findings it is postulated that the extr
act mediates its antinociceptive activity via
a complex interplay of various neurotrans
mitter syste-ms which may be mediated
both centrally and peripherally | en |
dc.language.iso | en | en |
dc.subject | Ocimum masaiense | en |
dc.subject | Pain | en |
dc.subject | Mechanism of action | en |
dc.subject | Antinociception | en |
dc.subject | Medicinal plants | en |
dc.title | Suppression of nociception by Ocimum masaiense root extract involves both central and peripheral mechanisms | en |
dc.type | Article | en |
local.publisher | Department of Chemistry, University of Nairobi | en |