Antinociceptive effects of stigmasterol and 9- Hexacosene isolated from mondia whytei (HOOK.F.) ROOT
Abstract
Mondiawhytei
is used for treatment of dysmennorrhea, gastro intestinal colic, post
-
partum pains among other uses in the
practice of traditional medicine in Africa.
In the present
study, the
in vivo
an
tinociceptive effects of two compounds,stigmasterol
and 9
-
hexacosene isolated from
Mondiawhytei
roots has been investigated.
Bioactivity guided
extraction and isolation of
stigmasterol and 9
-
hexacosene was carried out.The formalin test was used inassessing t
he antinociceptive activity.Stigmasterol
reduced the time spent licking, biting and/or lifting the injected paw in both the early and late phases of the formalin test
. This
reduction was found to be dose dependent and statistically significant (p<0.001) at
a dose of 30mg/kg body weight.9
-
hexacosene
produced dose
-
dependent and statistically significant (p<0.001) antinociceptive effect on the late phase of the formalin test at a
dose of 7.5mg/kg body weight.No motor, neurological or other behavioral deficits
were observed.
Conclusion:
Results of the present study supported the utilization of
Mondiawhytei
in Africa folk medicine and revealed
stigmasterol and 9
-
hexacosene as the major antinociceptive principles in the roots
URI
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Citation
Githinji.C.G . et al . / International Journal of Phytopharmacology. 2011, 2(2 ) , 70 - 75 .Publisher
Department of Medical Physiology School of Medicine