Effects of pethidine, acetylsalicylic acid, and indomethacin on pain and behavior in the mole-rat
dc.contributor.author | Kanui, Titus I | |
dc.contributor.author | Towett, Phelimon K | |
dc.date.accessioned | 2013-06-20T15:15:22Z | |
dc.date.available | 2013-06-20T15:15:22Z | |
dc.date.issued | 1993-05 | |
dc.identifier.citation | Volume 45 Issue 1 May 1993 Pages 153–159 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/37011 | |
dc.description.abstract | The antinociceptive and behavioral effects of pethidine (10, 20, or 30 mg/kg), acetylsalicylic acid (200, 400, or 600 mg/kg) and indomethacin (20, 40, or 50 mg/kg) in the naked mole-rat was studied in the hot-plate test. Instead of inducing analgesia, pethidine caused a dose-dependent reduction in response latency. Sensorimotor impairment and aggressive behavior were also observed following administration of pethidine (20 or 30 mg/kg). All animals recieving pethidine (30 mg/kg) died following fighting when kept in colony cages. Aggressive behavior and death was prevented by naloxone or by keeping animals in single cages. Acetylsalicylic acid (600 mg/kg) and indomethacin (40 or 50 mg/kg) caused a significant increase in response latency. It is concluded that in the mole-rat pethidine elicits aggression, sensorimotor impairment, and apparent hypergesia. | en |
dc.language.iso | en | en |
dc.subject | Naked mole-rat | en |
dc.subject | Hot-plate test | en |
dc.subject | Sensorimotor impairment | en |
dc.subject | Aggression | en |
dc.subject | Nociception | en |
dc.subject | NSAIDs | en |
dc.subject | Pethidine | en |
dc.title | Effects of pethidine, acetylsalicylic acid, and indomethacin on pain and behavior in the mole-rat | en |
dc.type | Article | en |
local.publisher | Department of Veterinary Anatomy and Physiology | en |
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