The first 9-hydroxyhomoisoflav anone, and antiplasmodial chalcones, from the aerial exudates of Polygonum senegalense
Date
2007Author
Midiwo, JO
Omoto, FM
Yenesew, A
Akala, HM
Wangui, J
Liyala, P
Wasunna, C
Waters, NC
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Phytochemical re-examination
of the aerial exudates of
Polygonum senegalense
forma
senegalense
has resulted in the isolation and ch
aracterization of a
novel homoisoflavonoid, 5,7-
dihydroxy-3-(hydroxy-phenyl-m
ethyl)-6-methoxy-chroman-4-
one (trivial name:
polygohomoisoflavanone). The structure was determ
ined on the basis of spectroscopic evidence.
The new compound along with other component
s of the aerial exudate showed good
antiplasmodial activities
towards chloroquine-sensitive (D6)
and chloroquine-resistant (W2)
strains of
Plasmodium falciparum.
URI
http://www.arkat-usa.org/get-file/23074/http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/37077
Citation
ARKIVOC 2007 (ix ) 21-27Subject
Polygonum senegalenseaerial exudates
polygonaceae
homoisoflavanone
polygohomoisoflavanone
chalcones
dihydrochalcone s
flavanone
malaria
plasmodium
anti- plasmodial