Antiparasitic and anticancer carvotacetone derivatives from Sphaeranthus bullatus
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Date
2012-09Author
Machumi F.
Yenesew Abiy.
Midiwo Jacob O.
Heydenreich M.
Kleinpeter E.
Khan S.
Tekwani BL.
Walker LA.
Muhammad I.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The 1:1 MeOH/CH2Cl2 extract of aerial parts of Sphaeranthus bullatus, an annual herb native to tropical East Africa, showed activity against chloroquine sensitive D6 (IC50 9.7µg/ml) and chloroquine resistant W2 (IC50 15.0µg/ml) strains of P. falciparum. Seventeen secondary metabolites were isolated and evaluated for their in-vitro antiplasmodial, antileishmanial and anticancer activities revealing activity on four carvotacetone derivatives 1-4; with antiplasmodial activity of IC50 3.4, 0.6, 0.8, 1.4µg/ml respectively against D6 strains of P. falciparum; antiplasmodial activity of IC50 2.8, 0.7, 0.9, 2.0µg/ml respectively against W2 strains of P. falciparum; antileishmanial activity of IC50 17.0, 0.7, 3.0 and 0.7 respectively against the parasite L. donovanii, and anticancer activity of IC50 <5.3µg/ml against SK-MEL, KB, BT-549 and SK-OV-3 cells for 2-4. In addition, cytotoxicity of the active compounds was evaluated against monkey kidney fibroblasts (VERO) and pig kidney epithelial (LLC-PK11) cells.
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https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0032-1320942http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/37112
http://www.ncbi.nlm.nih.gov/pubmed/23074885
Citation
Planta Med 2012; 78 - PI255Publisher
Department of Chemistry, University of NairobI