Antimicrobial Abietane Diterpenoids from Clerodendrum eriophyllum
Date
2010Author
Machumi, F
Samoylenko, V
MR Jacob
Wiggers, FT
Hester, JP
Midiwo, JO
Walker, LA
Muhammad, I
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Clerodendrum eriophyllum Gürke (Verbenaceae) is a shrub or small tree distributed in the dry bushlands of Eastern Kenya. The plant has no record of previous phytochemical analysis. A bioassay guided isolation of the methanol extract of C. eriophyllum afforded one new abietane diterpenoid, namely 12-hydroxy-8,12-abietadiene-3,11,14-trione (1) and nine known abietane analogs (2-10). The structures of the compounds 1-10 were determined by 1D and 2D NMR spectra, including COSY, HMQC and HMBC experiments, and ESI-HRMS. The isolated compounds 3, 6-8 exhibited in vitro antimicrobial activity against a panel of microorganisms, including potent activities against C. neoformans by 3 and 7 with IC50 0.58 and 0.96µg/mL respectively. Circular Dichroism (CD) spectra of isolated compounds 1, 3, 6-8 were registered to evaluate the stereochemistry.
URI
https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0030-1251830http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/37161
Citation
Planta Med 2010; 76 - P68Publisher
Department of Chemistry, University of Nairobi