dc.contributor.author | Yole, DS | |
dc.contributor.author | Gikuru, SK | |
dc.contributor.author | Wango, EO | |
dc.contributor.author | Kithome, K | |
dc.contributor.author | Kiarie, S | |
dc.contributor.author | Limo, M | |
dc.date.accessioned | 2013-06-21T12:13:08Z | |
dc.date.available | 2013-06-21T12:13:08Z | |
dc.date.issued | 2006-01 | |
dc.identifier.citation | Afr J Health Sci. 2006 Jan-Jun;13(1-2):47-54 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/?term=Influence+of+age+of+mice+on+the+susceptibility+to+murine+schistosomiasis+infection | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/37523 | |
dc.description.abstract | Intensity of human schistosomiasis infection increases with age, a peak being attained at early puberty. Hormones could be involved in the age-related changes in susceptibility to schistosomiasis. Male BALB / c mice were infected with Schistosoma mansoni either before or after puberty and worm numbers, cellular immune responses, hormonal levels and pathology analysed. Pre-puberty infected mice had a significantly higher number of adult worms (p < 0.05), more severe granulomas, higher mortality rate and higher proliferative responses as compared to post-puberty infected mice. Levels of the hormones were lower in the pre-puberty infected mice as compared to the post-puberty group early in the infection. Plasma levels of testosterone and luteinizing hormones decreased significantly (p < 0.05) in infected mice when compared to controls. Susceptibility to S. mansoni in male BALB / c mice seems to be influenced by levels of testosterone and luteinizing hormone at infection. Albeit, an infection with S. mansoni seems to lower the hormonal levels. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Influence Of Age Of Mice On The Susceptibility To Murine Schistosomiasis Infection | en |
dc.type | Article | en |
local.publisher | Institute of Primate Research | en |