Oestradiol And Progesterone Receptor Concentrations And The Metabolism Of Oestrogen In Uterine Leiomyomata.
Date
2002Author
Wango, EO
Tabifor, NH
Makawiti, DW
Kigondu, CS
Muchiri, LW
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The contents of progesterone and oestrogen, and their respective receptors in uterine leiomyomata and adjacent normal myometrial tissue in indigenous black women in Kenya were studied. A random selection of twenty women undergoing hysterectomy for uterine fibroids at Kenyatta National Hospital was used for the studies. The myometria contained higher levels of E(2 ) (181% : P < 0.001); and P(4 ) (240.6 % : P < 0.001); as compared to the leiomyomata. On the other hand uterine leiomyomata contained significantly higher levels of ER (147.6% : P < 0.001); and PR (178.7% : P < 0.001 ); than normal myometria. These findings differ slightly from those reported in black women in developed countries, but support the proposal that manipulation of sex steroids may be useful in the treatment and management of uterine leiomyomata.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/37627http://www.ncbi.nlm.nih.gov/pubmed/17298155
Citation
Wango EO, Tabifor HN, Muchiri LW, Sekadde-Kigondu C and Makawiti DW. (2002). Oestradiol And Progesterone Receptor Concentrations And The Metabolism Of Oestrogen In Uterine Leiomyomata; Afr J Health Sci. 2002 Jul-Dec;9(3-4):123-8.Publisher
University of Nairobi Faculty Of Veterinary Medicine