| dc.contributor.author | Vierling, W | |
| dc.contributor.author | Gathumbi, J | |
| dc.contributor.author | Salah, AM | |
| dc.date.accessioned | 2013-06-21T15:01:17Z | |
| dc.date.available | 2013-06-21T15:01:17Z | |
| dc.date.issued | 2002-05 | |
| dc.identifier.citation | Phytother Res. 2002 May;16(3):283-5. | en |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/37753 | |
| dc.description.abstract | The methanol extracts of Hibiscus sabdariffa (p < 0.01) showed a significant dose dependent relaxant effect (IC50) = 350 microM) on rat ileal strip comparable to the effect shown by nifedipin and papaverine as reference compounds. Similarly, the extract when administered intraperitoneally significantly (p < 0.05-0.01) reduced the intestinal transit (13%-35%) in rats (IC50, = 250 microM). The extracts (40% +/- 04%) and nifedipin (51% +/- 05%) also potentiated the diarrhoea inducing effect of castor oil (IC50 = 350 microM). It is postulated that these effects are possibly generated by constituents such as quercetin and eugenol via a Ca2+ channel modulated mode of action. | en |
| dc.language.iso | en | en |
| dc.title | Inhibition of intestinal motility by methanol extracts of Hibiscus sabdariffa L. (Malvaceae) in rats. | en |
| dc.type | Article | en |
| local.publisher | Department of Veterinary Pathology, Microbiology & Parasitology | en |
