Browsing College of Health Sciences (CHS) by Author "Appleby, T"

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    • The Discovery of GS-9669, a Thumb Site II Non-nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection 

      Lazerwith, SE; Lew, W; Zhang, J; Morganelli, P; Liu, Q; Canales, E; Clarke, MO; Doerffler, E; Byun, D; Mertzman, M; Ye, H; Chong, L; Xu, L; Appleby, T; Chen, X; Fenaux, M; Hashash, A; Leavitt, SA; Mabery, E; Matles, M; Mwangi, Julius W.; Tian, Y; Lee, YJ; Zhang, J; Zhu, C; Murray, BP; Watkins, WJ (University of NairobiDepartment of Pharmacology And Pharmacognosy, 2013-11-06)
      Investigation of thiophene-2-carboxylic acid HCV NS5B site II inhibitors, guided by measurement of cell culture medium binding, revealed the structure-activity relationships for intrinsic cellular potency. The pharmacokinetic ...