A novel Steroid1 from Elephantopus scaber L. an Ethnomedicinal plant with antidiabetic activity
Date
2009-03Author
P, Daisy
R, Jasmine
S, Ignacimuthu
E, Murugan
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Acetone extract of Elephantopus scaber, an ethnomedicnal plant, reduced the blood glucose levels in streptozotocin-induced diabetic rats significantly. Acute toxicity studies revealed the non-toxic nature of the crude extract. Fractionation of the acetone extract yielded a new steroid, 28Nor-22(R)Witha 2,6,23-trienolide. Biological testing of the compound demonstrated a significant antidiabetic activity by reducing the elevated blood glucose levels and restoring the insulin levels in streptozotocin-induced diabetic rats. This compound can be a useful candidate to treat diabetes.
URI
http://www.sciencedirect.com/science/article/pii/S0944711308001074http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/47282
Citation
P. Daisy, R. Jasmine, S. Ignacimuthu, E. Murugan;A novel Steroid1 from Elephantopus scaber L. an Ethnomedicinal plant with antidiabetic activity ;Phytomedicine, Volume 16, Issues 2–3, March 2009, Pages 252–257;http://dx.doi.org/10.1016/j.phymed.2008.06.001Publisher
University of Nairobi College of Biological and Physical Sciences