A novel Steroid1 from Elephantopus scaber L. an Ethnomedicinal plant with antidiabetic activity
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Acetone extract of Elephantopus scaber, an ethnomedicnal plant, reduced the blood glucose levels in streptozotocin-induced diabetic rats significantly. Acute toxicity studies revealed the non-toxic nature of the crude extract. Fractionation of the acetone extract yielded a new steroid, 28Nor-22(R)Witha 2,6,23-trienolide. Biological testing of the compound demonstrated a significant antidiabetic activity by reducing the elevated blood glucose levels and restoring the insulin levels in streptozotocin-induced diabetic rats. This compound can be a useful candidate to treat diabetes.
CitationP. Daisy, R. Jasmine, S. Ignacimuthu, E. Murugan;A novel Steroid1 from Elephantopus scaber L. an Ethnomedicinal plant with antidiabetic activity ;Phytomedicine, Volume 16, Issues 2–3, March 2009, Pages 252–257;http://dx.doi.org/10.1016/j.phymed.2008.06.001
University of NairobiCollege of Biological and Physical Sciences