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    Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis

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    Date
    2013
    Author
    Diab, A
    Zickl, L
    Abdel-Wahab, O
    Jhanwar, S
    Gulam, MA
    Panageas, KS
    Patel, JP
    Jurcic, J
    Maslak, P
    Paietta, E
    Mangan, JK
    Carroll, M
    Fernandez, HF
    Teruya-Feldstein, J
    Luger, SM
    Douer, D
    Litzow, MR,
    Lazarus, HM
    Rowe, JM
    Levine, RL
    Tallman, MS
    Type
    Article
    Language
    en
    Metadata
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    Abstract
    Previous small series have suggested that acute myeloid leukemia with t(8;16) is a distinct morphologic and clinical entity associated with poor prognosis. We describe 18 patients with t(8;16) AML, including their clinical, cytomorphologic, immunophenotypic and cytogenetic features. Half of the patients had extramedullary disease, most commonly leukemia cutis, which often preceded bone marrow involvement and six had therapy-related AML. Patients with t(8;16) AML commonly present with clinical and pathological features that mimic APL, with promyelocytes and promyeloblast-like cells and coagulopathy in most patients. Several patients also presented with marrow histiocytes with hemophagocytosis and erythrophagocytosis. Comprehensive molecular analysis for co-occurring genetic alterations revealed a somatic mutation in RUNX1 in 1 of 6 t(8;16) patients with no known AML mutation in the remaining five t(8;16) patients. This suggests that the t(8;16) translocation could be sufficient to induce hematopoietic cell transformation to AML without acquiring other genetic alteration. These data further support classifying t(8;16) AML as a clinically and molecularly defined subtype of AML marked by characteristic clinical and cytomorphologic features that mimic APL, and is associated with very poor survival
    URI
    http://www.ncbi.nlm.nih.gov/pubmed/23102703
    http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57955
    Publisher
    College of Biological and Physical Sciences ,Department of physics
    Collections
    • Faculty of Science & Technology (FST) [4264]

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