An In Vitro Study On The Oxytocic Action Of Adenia Globosa Engl
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Date
2013-06Author
Sinei, Kipruto A
Mwangi, Julius W
Munenge, Rahab W
Mwaura, Amos M
Type
PresentationLanguage
enMetadata
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Objectives: The objectives of the study was to investigate the effect of the water
extract of Adenia globosa on the isolated preparation of the rat uterus and how
this could be affected by well known uterine stimulants such as ergometrine and
prostaglandin F2α. and also by antagonists of acetylcholine and adrenaline.
Setting: Department of Pharmacology and Pharmacognosy Laboratory, School
of Pharmacy, University of Nairobi, KNH Campus
Study Design: It was a laboratory based study. The crude extract and the other
drugs were tested on isolated rat uterus set up in an organ bath under the usual
laboratory conditions.
Results: The results obtained showed that the plant extract caused a dosedepended
contraction of the rat uterus which was not antagonized by atropine
nor phenoxybenzamine. The contractile effect was however potentiated by small
doses of ergometrine and prostaglandin F2α.
Conclusions: It was concluded from these observations that the contractile
action was not mediated through cholinergic nor adrenergic system. Secondly, it
was postulated that since prostaglandin F2α is also released at the time of labour,
the potentiatory action probably occurs in vivo when the plant preparation is
given to domestic animals to ease and speed up the process of giving birth as
claimed in the traditional use of this plant.
Citation
Sinei, Kipruto A.,Mwangi, Julius W.,Munenge, Rahab W.,Mwaura, Amos M.;An In Vitro Study On The Oxytocic Action Of Adenia Globosa Engl;paper presented at the 2nd International Scientific Conference, Chs And Knh, 19th - 21st June 2013.Publisher
University of Nairobi College of Health Sciences
Description
An In Vitro Study On The Oxytocic Action Of Adenia Globosa Engl;paper presented at the 2nd International Scientific Conference, CHS And KNH, 19th - 21st June 2013.