Glomerular Filtration Rate Assessment Using Creatinine Related Parameters For Healthy Adult Kenyan Population
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Date
2013-06Author
Waithaka, Stanley K
Type
PresentationLanguage
enMetadata
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Objective: The purpose of the study was to establish the reference ranges of
measured creatinine clearance and estimated creatinine clearance for adult
Kenyan population.
Method: A prospective study carried out in clinical chemistry laboratory
of Kenyatta National Hospital involving 265 healthy individuals between
18-60years.
Reference ranges were constructed by using the parametric methods to estimate
2.5 and 97.5 percentiles of distribution as lower and upper reference limits. The
glomerular filtration rate assessment of the adult healthy Kenyan population was
carried out by investigating serum creatinine (SrCr), 24 hours urine creatinine
clearance (Mcrcl), estimated creatinine clearance (Ecrcl), urine creatinine (UCr)
and urine volume (UV). Two hundred and sixty five voluntarily study subjects
comprising of 106 male and 159 females were recruited in the study.
Results: Sex related reference values were established as follows:- SrCr
[male:68-128), female: 60-122] umol/l, Mcrcl [male:52-110), female: 60-122]
ml/min, Ecrcl [male:54-118), female: 58-106]ml/min, UCr [male:3588-10,400),
female: 3262-9886] umol/l and UV [male:875-2301, female: 802-2092] ml/24
hrs.
Same sex mean difference was found for the established reference ranges of
Mcrcl and Ecrcl (male p=0.021 and female p=0.000).Decline rate in creatinine
clearance in the ages under investigation were: male measured creatinine
clearance (0.46 ml/min per year), male estimated creatinine clearance (0.29ml/
min), female measured creatinine clearance (0.39 ml/min per year) and female
estimated creatinine clearance (0.2ml/min).
Conclusion: Sex specific reference ranges for the assessment of glomerular
filtration rate has been established. Age is an important factor in the interpretation
of creatinine clearance of an individual. These reference ranges are different
from those reported in literature, therefore each clinical chemistry laboratory
should establish its own.
Keywords: reference range, glomerular filtration rate, adult Kenyan, Kenyatta
national hospital
Citation
Waithaka,Stanley K.;June,2013.Glomerular Filtration Rate Assessment Using Creatinine Related Parameters For Healthy Adult Kenyan Population,presented at the 2nd International Scientific Conference, CHS And KNH, 19th - 21st June 2013.Publisher
University of Nairobi College of Health Sciences
Description
Glomerular Filtration Rate Assessment Using Creatinine Related Parameters For Healthy Adult Kenyan Population,presented at the 2nd International Scientific Conference, CHS And KNH, 19th - 21st June 2013.