Clinical Course And Outcome Of HIV Positive Children Resident At A Children’s Home In Nairobi: A 15 Year Review (1995-2010)
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Date
2013-06Author
Musoke, R
Palakudy, T
Panikulam, A
Owens, M
Lwembe, R
Lihana, R
Songok, EM
Ichimura, H
Type
PresentationLanguage
enMetadata
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Background: Availability of antiretroviral therapy (ART) has changed the
outcome of HIV. Prior to 2005 drug supply was erratic, paediatric formulations
difficult to get and costs were prohibitive.
Method: The current is a retrospective report on outcome 207 HIV infected
children we have consistently followed up clinically since 1995, immunological
and virology since 1998 and ART since 1999.
Results: Out of the 207 children 146 (70.5%) are alive, and 61 (29.5%) have
died. Mean age at admission was 4.7yrs (range 2 months to 14yrs) and end of
2010 mean age was 14yrs (range of 2yrs to 24yrs) Most of the deaths were
in the period before availability of ARVs. Eleven of the 17 children who died
after 2000 were on ART. At the start of therapy 71 (63.4%) had WHO stage 3/4
disease.
The most common condition was chronic lung disease 36 (32.1%). Majority of
children improved clinically and immunologically. But CD4 counts remained
low for age in 16 children. Since the start of ART, 57 children are on first line
drugs while 55 are on second line and 20 are not on treatment. Viral load of
children on first line became undectable within 6 months in 66.7% while others
took up to 24 months. Forty six children who never responded to first line drugs
despite clinical and immunological response had resistant mutations.
Citation
Musoke, R.,Palakudy, T.,Panikulam, A., Owens, M., Lwembe, R., Lihana, R., Songok, E.M., Ichimura, H.;June,2013.Clinical Course And Outcome Of HIV Positive Children Resident At A Children’s Home In Nairobi: A 15 Year Review (1995-2010),presented at the 2nd International Scientific Conference, CHS And KNH, 19th - 21st June 2013.Publisher
University of Nairobi College of Health Sciences
Description
Clinical Course And Outcome Of HIV Positive Children Resident At A Children’s Home In Nairobi: A 15 Year Review (1995-2010),presented at the 2nd International Scientific Conference, CHS And KNH, 19th - 21st June 2013.