Cytotoxic Quinones from the Roots of Aloe dawei.

dc.contributor.author	Abdissa, N
dc.contributor.author	Induli, M
dc.contributor.author	Fitzpatrick, P
dc.contributor.author	Alao, JP
dc.contributor.author	Sunnerhagen, P
dc.contributor.author	Landberg, G
dc.contributor.author	Yenesew, A
dc.contributor.author	Erdélyi, M
dc.date.accessioned	2014-03-20T09:50:27Z
dc.date.available	2014-03-20T09:50:27Z
dc.date.issued	2014-03-17
dc.identifier.citation	Molecules. 2014 Mar 17;19(3):3264-3273.	en_US
dc.identifier.uri	http://www.ncbi.nlm.nih.gov/pubmed/24642911
dc.identifier.uri	http://hdl.handle.net/11295/65391
dc.description.abstract	Seven naphthoquinones and nine anthraquinones were isolated from the roots of Aloe dawei by chromatographic separation. The purified metabolites were identified by NMR and MS analyses. Out of the sixteen quinones, 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone is a new compound. Two of the isolates, 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione and 1-hydroxy-8-methoxy-3-methylanthraquinone showed high cytotoxic activity (IC50 1.15 and 4.85 µM) on MCF-7 breast cancer cells, whereas the others showed moderate to low cytotoxic activity against MDA-MB-231 (ER Negative) and MCF-7 (ER Positive) cancer cells.	en_US
dc.language.iso	en	en_US
dc.publisher	University of Nairobi	en_US
dc.title	Cytotoxic Quinones from the Roots of Aloe dawei.	en_US
dc.type	Article	en_US

Files in this item

Files	Size	Format	View
There are no files associated with this item.