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Neurotrophic And Antileukemic Daphnane Diterpenoids From Synaptolepis Kirkii

dc.contributor.authorHe, Weidong
dc.contributor.authorCik, Miroslav
dc.contributor.authorVan Puyvelde, Luc
dc.contributor.authorVan Dun, Jacky
dc.contributor.authorAppendino, Giovanni
dc.contributor.authorLesage, Anne
dc.contributor.authorVan der Lindin, Ilse
dc.contributor.authorLeysen, Josée E
dc.contributor.authorWouters, Walter
dc.contributor.authorMathenge, Simon G
dc.contributor.authorMudida, Francis P
dc.contributor.authorDe Kimp, Norbert
dc.date.accessioned2014-04-02T06:50:16Z
dc.date.available2014-04-02T06:50:16Z
dc.date.issued2002-10
dc.identifier.citationBioorganic & Medicinal Chemistry Volume 10, Issue 10, October 2002, Pages 3245–3255en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0968089602001633
dc.identifier.urihttp://hdl.handle.net/11295/65716
dc.description.abstractBiological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in vitro assays. A bioassay-guided fractionation led to the isolation of kirkinine (6), kirkinine B (7), C (8), D (3), E (9), synaptolepis factor K7 (1), excoecariatoxin (2), yuanhuadine (4) and 12β-acetoxyhuratoxin (5) from the root of Synaptolepis kirkii, which possess potential neurotrophic and antileukaemia activities.en_US
dc.language.isoenen_US
dc.publisherUniversity of Nairobien_US
dc.titleNeurotrophic And Antileukemic Daphnane Diterpenoids From Synaptolepis Kirkiien_US
dc.typeArticleen_US


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