| dc.contributor.author | Yusuf, Amir | |
| dc.contributor.author | Gitu, Peter | |
| dc.contributor.author | Bhatt, Bhalendu | |
| dc.contributor.author | Njogu, Martin | |
| dc.contributor.author | Salim, Ali | |
| dc.contributor.author | Orata, Duke | |
| dc.date.accessioned | 2014-07-03T05:45:10Z | |
| dc.date.available | 2014-07-03T05:45:10Z | |
| dc.date.issued | 2014 | |
| dc.identifier.citation | Amir Yusuf, Peter Gitu, Bhalendu Bhatt, Martin Njogu, Ali Salim, Duke Orata (2014). Solid-Phase Peptide Synthesis of Arginine-vasopressin with Amide Side-chain of Asparagine Protected with 1-Tetralinyl Group. Chemistry and Materials Research, 6(4), 60-65. | en_US |
| dc.identifier.uri | http://iiste.org/Journals/index.php/CMR/article/view/12157 | |
| dc.identifier.uri | http://hdl.handle.net/11295/71694 | |
| dc.description.abstract | Arginine-vasopressin, a nonapeptide amide, was synthesized on a benzhydryl-resin using the Boc-strategy. Benzyl group was used in the protection of sulfhydryl group of cysteine and tyrosine side-chain. Benzhydryl, tetralinyl and tosyl groups were used in the protection of glutamine, asparagine and arginine side-chains respectively. TFMSA-TFA-thioanisole-1,2-ethanedithiol (2:20:2:1 v/v) was used to cleave the peptide from the resin under different conditions to obtain arginine-vasopressin in a one-pot reaction. The cleavage at 40°C for two hours gave arginine-vasopressin quantitatively (77% yield)
Keywords: Solid-Phase Peptide Synthesis, resin, protecting group, cleavage, nonapeptide | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | University of Nairobi | en_US |
| dc.title | Solid-Phase Peptide Synthesis of Arginine-vasopressin with Amide Side-chain of Asparagine Protected with 1-Tetralinyl Group | en_US |
| dc.type | Article | en_US |
