The Effect of 3,6,bis-Dimethylaminoacridine on Cultured Bovine Lymphoid Cells Infected with Theileria Parva and in Cattle Experimentally Infected with East Coast Feuer
Abstract
The cytocidal effect of 3,6,bis-dimethylaminoacridine (A. O.) on Theileria parva — infected bovine lymphoblastoid cells was investigated by growing the cells in media containing varying concentrations of the drug for 24 to 48 hours or exposing them to 5 μg./ml. for 1 to 15 minutes. Cell growth was affected by as little as 0.01 μg./ml. A. O., while 2 μg./ml. in culture media killed all cells within 48 hours. Exposure of cells to 5 μg./ml. A. O. for even 1 minute was sufficient to cause fatal injury. In vivo studies in cattle experimentally infected with T. parva showed that A. O. at 2 or 5 mg./kg. could not prevent death in the diseased animals but the time from infection to appearance of piroplasms was longer in the treated than in the control animals.
URI
http://onlinelibrary.wiley.com/doi/10.1111/j.1439-0450.1975.tb00577.x/abstracthttp://hdl.handle.net/11295/73031
Citation
Muhammed, S. I. "The Effect of 3, 6, bis‐Dimethylaminoacridine on Cultured Bovine Lymphoid Cells Infected with Theileria Parva and in Cattle Experimentally Infected with East Coast Feuer." Zentralblatt für Veterinärmedizin Reihe B 22.2 (1975): 169-175.Publisher
University of Nairobi,