Evaluation of Antidiabetic Effects kleinia Squarrosa on Alloxanized Diabetic Mice

Abstract

Diabetes mellitus is a disease of antiquity with a worrying global prevalence and incidence. It is conventionally managed by insulin and use of oral hypoglycemic drugs besides exercise, diet and physical intervention therapies. Use of insulin and oral hypoglycemic agents is bedeviled by the fact that they are costly and have numerous adverse effects. Medicinal plants have for long been used for treatment of many disease including management of diabetes mellitus. They habour the pros of affordability and accessibility. This study was designed to bioscreen aqueous stem bark extracts of kleinia squarrosa for its blood glucose lowering potential. The three tested dose levels (50, 100, and 150mg/kg body weight) lowered blood glucose levels significantly. This study has established that the aqueous stem bark extract of kleinia squarrosa has antidiabetic effects and can justifiably be used for management of diabetes mellitus.