3-Oxo-14α,15α-epoxyschizozygine: A new schizozygane indoline alkaloid from Schizozygia coffaeoides
Date
2014-07Author
Atilaw, Yoseph
Heydenreich, Matthias
Ndakala, Albert
Language
enMetadata
Show full item recordAbstract
The stem bark extract of the Schizozygia coffaeoides (Apocynaceae) showed moderate antiplasmodial activity (IC50 = 8–12 μg/mL) against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the extract led to the isolation of a new schizozygane indoline alkaloid, named 3-oxo-14α,15α-epoxyschizozygine. In addition, two dimeric anthraquinones, cassiamin A and cassiamin B, were identified for the first time in the family Apocynaceae. The structures of the isolated compounds were deduced on the basis of spectroscopic evidence. The schizozygane indole alkaloids showed good to moderate antiplasmodial activities (IC50 = 13–52 μМ).
Graphical abstract
From stem bark extract of the Schizozygia coffaeoides, a new schizozygane indoline alkaloid named 3-oxo-14α, 15α-epoxyschizozygine was isolated along with known compounds. The alkaloids showed medium to weak antiplasmodial activites.
URI
http://www.sciencedirect.com/science/article/pii/S1874390014001219http://hdl.handle.net/11295/73377
Citation
Atilaw, Y., Heydenreich, M., Ndakala, A., Akala, H. M., Kamau, E., & Yenesew, A. (2014). 3-Oxo-14α,15α-epoxyschizozygine: A new schizozygane indoline alkaloid from Schizozygia coffaeoides. Phytochemistry LettersPublisher
University of Nairobi