Larvicidal Activities Of The Stem Bark Extract And Rotenoids Of Millettia Usaramensis Subspecies Usaramensis On Aedes Aegypti L. (diptera: Culicidae)
Date
2014Author
. Bosire, Carren M
Deyou, Tsegaye
. Kabaru, Jacques M
Kimataa, Dennis M.
Yenesewb, Abiy
Language
enMetadata
Show full item recordAbstract
The dichloromethane/methanol (1:1) extract of the stem bark of Millettia usaramensis subspecies usaramensis was tested for its larvicidal activity against the 4th instar Aedes aegypti larvae and demonstrated activity with LC50 value of 50.8 ± 0.06 μg/mL at 48 h. Compounds isolated from the extract were also tested for their larvicidal activities, and the rotenoid usararotenoid-A (LC50 4.3 ± 0.8 μg/mL at 48 h) was identified as the most active principle. This compound appears to be the first rotenoid having a trans-B/C ring junction and methylenedioxy group at C-2/C-3 with high larvicidal activity. Related rotenoids with the same configuration at the B/C-ring junction did not show significant activity at 100 μg/mL.
Graphical abstract
The stem bark extract of Millettia usaramensis showed larvicidal activity against Aedes aegypti. Usararotenoid-A was identified as the most active principle.
URI
http://www.sciencedirect.com/science/article/pii/S1226861514000636http://hdl.handle.net/11295/73443
Citation
Bosire, C. M., Deyou, T., Kabaru, J. M., Kimata, D. M., & Yenesew, A. (2014). Larvicidal activities of the stem bark extract and rotenoids of Millettia usaramensis subspecies usaramensis on Aedes aegypti L. (Diptera: Culicidae). Journal of Asia-Pacific Entomology , 17(3), PP. 531–535Publisher
University of Nairobi