Inhibition By Tryptophan Of Nucleolar Rna Synthesis In Salivary Gland Nuclei Of Chironomus Thummi
Abstract
Tryptophan, but not glutamine and lysine, inhibits the incorporation of3H-uridine into nucleoli of explanted salivary glands by about 60%. In isolated nuclei also, the nucleolar incorporation of3H-uridine triphosphate is reduced to about 50% by tryptophan. It is concluded that tryptophan acts directly at the nuclear level and the possible mechanisms involved are discussed.
Citation
Experientia 15. 11. 1979, Volume 35, Issue 11, pp 1501-1503Publisher
University of Nairobi