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Now showing items 41-50 of 55
Prevalent neuropathy in a cohort of HIV-infected Kenyan sex workers using antiretroviral drugs.
(University of Nairobi, 2016)
INTRODUCTION:
Several risk factors including stavudine and age have been strongly associated with polyneuropathy. However, conflicting data exist on height as an independent risk factor in polyneuropathy. The objective ...
Sexual Assault and HIV Postexposure Prophylaxis at an Urban African Hospital.
(University of Nairobi, 2017)
Antiretroviral postexposure prophylaxis (PEP) may be underutilized in sexual assault cases in Kenya. This study evaluated the characteristics of survivors of sexual violence attending the Gender-Based Violence Recovery ...
The incidence of first-line antiretroviral treatment changes and related factors among HIV-infected sex workers in Nairobi, Kenya.
(University of Nairobi, 2017)
INTRODUCTION:
In many settings, several factors including adverse drug reactions and clinical failure can limit treatment choices for combined antiretroviral therapy (cART). The aim of the study was to describe the incidence ...
Regulation of mucosal and systemic immune activation during the menstrual cycle of female sex workers from nairobi, kenya; local regulation and HIV-induced impairment
(University of Nairobi, 2015)
Problem:
Vaginal intercourse is the main route of HIV infection among women. To result in a productive infection, HIV must encounter activated targets that sustain replication. Sexual hormones modulate activation and ...
Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells.
(University of Nairobi, 2015)
Elevated inflammatory cytokines (EMCs) at mucosal surfaces have been associated with HIV susceptibility, but the underlying mechanisms remain unclear. We characterized the soluble mucosal proteome associated with elevated ...
Murine Plasmodium chabaudi malaria increases mucosal immune activation and the expression of putative HIV susceptibility markers in the gut and genital mucosa.
(University of Nairobi, 2013-11)
To evaluate if systemic murine malarial infection enhances HIV susceptibility through parasite-induced mucosal immune alterations at sites of HIV sexual exposure.
BACKGROUND::
Malaria and HIV have a high degree of ...
Anti-HIV-1 activity of elafin depends on its nuclear localization and altered innate immune activation in female genital epithelial cells.
(University of Nairobi, 2012-12-27)
Elafin (E) and its precursor trappin-2 (Tr) are alarm antiproteases with antimicrobial and immunomodulatory activities. Tr and E (Tr/E) have been associated with HIV-1 resistance. We recently showed that Tr/E reduced IL-8 ...
Hiv-specific Cd8+ T-cell Proliferation Is Prospectively Associated With Delayed Disease Progression.
(University of Nairobi, 2012-03)
Human immunodeficiency virus (HIV)-specific CD8(+) T-cell proliferation is consistently correlated with enhanced host HIV immune control, but whether proliferative responses are a cause or consequence of immune protection ...
Mucosal Serpin A1 And A3 Levels In Hiv Highly Exposed Sero-negative Women Are Affected By The Menstrual Cycle And Hormonal Contraceptives But Are Independent Of Epidemiological Confounders.
(University of Nairobi, 2013-01)
OBJECTIVE:
Serpins (serine protease inhibitors) are associated with protection against HIV infection. Here, we characterized mucosal serpin expression in the genital tract of HIV highly exposed sero-negative (HESN) women ...