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Now showing items 11-19 of 19
Genital levels of soluble immune factors with anti-HIV activity may correlate with increased HIV susceptibility
(University of Nairobi, 2008-10)
Despite the scale of the HIV pandemic, mucosal innate immune defenses prevent HIV infection after most sexual exposures. Several soluble immune factors with in vitro anti-HIV activity are present at the genital mucosa in ...
Molecular Definition Of Vaginal Microbiota In East African Commercial Sex Workers
(University of Nairobi, 2011-06)
Resistance to HIV infection in a cohort of commercial sex workers living in Nairobi, Kenya, is linked to mucosal and antiinflammatory factors that may be influenced by the vaginal microbiota. Since bacterial vaginosis (BV), ...
Relative HIV Resistance In Kenyan Sex Workers Is Not Due To An Altered Prevalence Or Mucosal Immune Impact Of Herpes Simplex Virus Type 2 Infection.
(University of Nairobi, 2009-09)
Chronic infection by herpes simplex virus type 2 (HSV-2) increases HIV susceptibility, perhaps due to HSV-2-associated increases in activated mucosal immune cells. A small number of Kenyan female sex workers (FSWs) exhibit ...
Novel Interferon Regulatory Factor-1 Polymorphisms In A Kenyan Population Revealed By Complete Gene Sequencing
(University of Nairobi, 2004)
Variation in susceptibility to HIV-1 infection depends on numerous factors, and host genetic variation has been well-described as an important component. As a transcriptional regulator, interferon regulatory factor 1 (IRF-1) ...
Full-length Hiv Type 1 Proviral Sequencing Of 10 Highly Exposed Women From Nairobi, Kenya Reveals A High Proportion Of Intersubtype Recombinants.
(University of Nairobi, 2008-06)
Phylogenetic analysis has revealed that the current HIV/AIDS pandemic consists of a multitude of different viral clades and recombinant viruses. The predominant circulating HIV-1 clade in Kenya is A1; however, Kenya borders ...
Anti-HIV-1 activity of elafin depends on its nuclear localization and altered innate immune activation in female genital epithelial cells.
(University of Nairobi, 2012-12-27)
Elafin (E) and its precursor trappin-2 (Tr) are alarm antiproteases with antimicrobial and immunomodulatory activities. Tr and E (Tr/E) have been associated with HIV-1 resistance. We recently showed that Tr/E reduced IL-8 ...
Role of Sexually Transmitted Infections in Accelerated HIV-1 Disease Progression
(University of nairobi, 2000)
Mucosal Serpin A1 And A3 Levels In Hiv Highly Exposed Sero-negative Women Are Affected By The Menstrual Cycle And Hormonal Contraceptives But Are Independent Of Epidemiological Confounders.
(University of Nairobi, 2013-01)
OBJECTIVE:
Serpins (serine protease inhibitors) are associated with protection against HIV infection. Here, we characterized mucosal serpin expression in the genital tract of HIV highly exposed sero-negative (HESN) women ...